Computational neuroimmunology
Multiple Sclerosis
Reanalyses of public brain data on the smoldering edge of MS lesions — the slow-burning rim that drives long-term disability and resists our best drugs.
Cellular census · interactive
The Smoldering Rim — a Cellular Census
What a chronic active MS lesion is made of, cell by cell: an interactive perivenular cross-section with the real cell-type composition of the active lesion edge, from a single-nucleus reanalysis.
Data analysis
Reading the Smoldering Edge of a Multiple Sclerosis Lesion
A reanalysis of public single-cell and spatial transcriptomics defining a molecular signature of the chronic active lesion rim — and an honest audit of what that signal does and does not show.
Methods post-mortem
The Envelope That Was Never There
How a “healthy expression” baseline drawn from too few control cells turned pure sampling noise into a false discovery — and the canonical rim signature the same method recovers once the baseline is drawn correctly.